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----- Original Message ----- From: Inhalation Toxicology Newsletter It is sent on the First of August, Swiss Independence Day. In this issue, we review some issues related to childhood asthma. Issues of particle size and drug delivery are also addressed. An inhalation employment opportunity notice at The Dow Chemical Company is listed below. Placement of notices such as this a free professional service. In the way of new technology, we showcase a capsule view of a novel binary exposure chamber from Canada. The inhalation exposure unit is described by the inventors, Josette Gunnette and Renaud Vincent. As you might expect, this patented system is available through CH Technologies. For more information on how it works, look at: "http://www.inhalation.net/exposure_unit.htm". If you wish, call Dr. Jaeger for more information and a demonstration at your facility. This unit will be displayed at the SOT meeting in San Francisco , March, 2001. The MicroDust 880 Pro from Casella is a new item. Their frequently asked questions (FAQS) pages are featured along with information on its operation. The text applies to earlier models and may be useful to those wishing to explain to management why such hardware is useful. This text from the Casella web side was assembled by Susan Shami. It is found at : "http://www.inhalation.net?microdust_pro.htm" Dr. Rudolph Jaeger will illustrate this unit along with the Vilnius Aerosol Generator (VAG) at the Association of Inhalation Toxicologists meeting in Stockholm, Sweden in September 13-15, 2000. A 30 port cigarette smoking machine with continuous flow smoke pumps is now available to University laboratories on a rental basis. A simpler version of this machine is available at reduced cost to universities, regulatory agencies or non-profit groups for use in their testing program. Contact Dr. Jaeger if you wish to know the rental cost and if you have a desire to schedule the availability of this unit. Details are found at "http://www.toxics.com". Articles/Issues of Current Interest in Inhalation Toxicology: The Role of the Government in Protecting the Health of Children and the suspected cause of asthma and recent legislative hearings are reviewed by Arlene Weiss at "http://www.inhalation.net/children.htm". Childhood Lung Disease and Urban Environmental Pollutants : Do Urban Environmental Pollutants Exacerbate Childhood Lung Disease? is described in this editorial from UC Davis. Susan Shami's comments and the citation are found at "http://www.inhalation.net/childhood_lung_disease.htm" A New Perspective on the Pathophysiology of Asthma from Dr. Sally E. Wenzel, MD, editor of the American Thoracic Society journal, is summarized by Dr. Shami at "http://www.inhalation.net/pathophysiology_asthma.htm". Particle Size and Asthma Treatment by Busse, WW, and Wenzel, SE, covers Large and Small Airway Dysfunction in Asthma: Rationale for Treating the Entire Airway. Dr. Shami notes that "Inflammation in the lungs of asthmatics seems most pronounced in small distal airways although central airways also show signs of inflammation". The rest of her review and commentary can be found at "http://www.inhalation.net/particle_size_and_asthma.htm". Crayon Follow-up While not necessarily connected in a cause and effect manner but after last month's newsletter note on Tremolite fiber release from crayons, the CPSC seems to have concluded the same as we did. No risk! However, in the interest of assuring the public, the respective companies have agreed to alter their formulations. The choice of materials is not yet known. Some of us have an interest in the inhalation hazards of talc, per se. For those that have an interest in this issue, I offer a communication we received from Richard Zazenski, Director Product Safety and Analytical Services at Luzenac America In. (303-643-0404). We asked about the purity of their talc products and whether all talc contains Tremolite fragments. "Luzenac America, Inc. certifies that all the talc products produced and sold by Luzenac America, including Nicron 504, do not contain detectable quantities of asbestos or asbestiform minerals (Tremolite, actinolite, anthophyllite) when analyzed via X-ray Diffraction (XRD), Polarized Light Microscopy (PLM), or Scanning Electron Microscopy with Energy Dispersive X-ray (SEM/EDX). Detection limits for SEM/EDX analyses depends on the number of fields examined (time of analysis), but is generally on the order of parts per million (ppm). Luzenac America utilizes its own Technical Center testing capabilities to monitor and validate this asbestos free certification. Luzenac America validates it's own testing protocol with an outside, independent laboratory. Please let me know if I can be of any further assistance. " The preceding was not paid for and is offered your for professional information only. Birth Announcement As a concerned grandfather, the Editor would certainly use talc of this quality on his newborn grand-daughter's delicate skin. For your information, her name is Jessica Lynn Squilanti, born 2:43 (or so) AM, July 31, 2000 in Ridgewood, New Jersey. This town was the home of the late Dr. Irving Sellikoff of Mt. Sinai Medical School. Congratulations to Tommy and Kristine Squilanti (-Jaeger) of Hillsdale, NJ, her proud parents. Prior newsletters and reports Prior issues of the newsletter are at: http://www.inhalation.net/newsletters.htm Professional Employment Opportunity POSITION TITLE: Technical Leader / Study Director - Respiratory Toxicology, Toxicology, Environmental Research and Consulting The Dow Chemical Company The Dow Chemical Company is a global science and technology based company that develops and manufactures a portfolio of chemical, plastic and agricultural products and services for customers in 168 countries around the world. With annual sales of more than $18 billion, Dow conducts its operations through 15 global businesses employing 39,000 people. The company has 123 manufacturing sites in 32 countries and supplies more than 3,500 products. Please visit our web site at www.dow.com. Equal opportunity employer offering a competitive compensation and benefits package including 401k, stock purchase, performance incentives, and educational assistance. JOB OVERVIEW: This individual will serve as the Technical Leader and a Study Director for the Respiratory Toxicology group of the Toxicology & Environmental Research and Consulting (TERC) Laboratory. As the Technical Leader, the candidate will be the scientific expert within TERC to address issues associated with the respiratory system as a target organ. TERC is a multi-disciplinary organization, and it is anticipated that the Technical leader in respiratory toxicology will establish collaborations with the other disciplines, such as immunotoxicology, neurotoxicology, repro/developmental toxicology, etc. As a Study Director, the candidate will be responsible for the management of acute and multi-exposure inhalation toxicity studies required by various governments for the purpose of registering products for marketing and also for product stewardship purposes. Responsibilities will include leading the staff in the respiratory toxicology group in the assembly and operation of exposure chambers, test atmosphere generation, and the use and calibration of electronic data collection systems. EDUCATION / CERTIFICATION REQUIREMENTS: The candidate must have a minimum of Ph.D. (or comparable degree) in toxicology, pathology or a related field with 2 years post-doctoral experience. The candidate should have a working knowledge of techniques in inhalation toxicology and an established record of competence in the area of respiratory toxicology. This job requires an individual with a high degree of initiative who can work independently yet be able to interface with scientists and technical staff across the laboratory. The job requires the ability to work with laboratory animals (rats, mice, rabbits, guinea pigs, dogs) during both in-life and post-inlife procedures. In addition to knowledge in respiratory toxicology, this job requires strong math and computer skills, well-developed communication, prioritization and organizational skills and extremely accurate record keeping. Experience with GLP is desired. The candidate will be handling multiple projects of varying lengths with fixed deadlines. CONTACT INFORMATION: Contact Ralph Albee, Senior Resource Leader 517-636-9087 (ralbee@dow.com) or Michael Holsapple, Research Scientist 517-636-4387 (mholsapple@dow.com) for additional information. A word from our sponsor, CH Technologies University Model - 30 Port Cigarette Smoking Machine Research scientists interested in the toxicology of tobacco smoke and related research may wish to avail themselves of a rental or rental-purchase program. A 30 port cigarette smoking machine is now available for use by university and educational research laboratories. The automatic device, computer controlled, smokes 80 to 120 mm standard cigarettes to FTC conditions. Both mainstream and side stream smoke can be generated continuously. Smoke protocols other than FTC such as the extreme ISO protocol and various regional protocols can be accommodated. The device is capable of multiple puffs each minute (up to 3) and can be used in smoke condensate studies. A less costly university model will be built to order. Contact Dr. Jaeger for details. Calendar of Upcoming Events: The calender of current and future events appears at: http://www.inhalation.net/calendar.htm . Address for Comments and Letters to the Editor The Editorial staff welcomes your questions and comments. Send them to sshami@bellatlantic.net or use the listings below. Changes, additions or to be removed from the e-mail list To make changes or to have your name deleted from our subscriber list, see the section entitled, Additions, Changes and Removals, found at the end of this message. If you find this forum useful, send your web address or email a copy of the newsletter to a colleague. Sponsors http://www.toxics.com. http://www.envmed.com. RSS Paracelsus GmbH, Diepoldsau, Switzerland Additions, Changes and Removals If a colleague wishes to be added to the
mailing list, send email to "Susan Jaeger" EDITORIAL STAFF Rudolph J. Jaeger, Ph.D., DABT + 201 666 2335 VOICE Publisher/Editor-in-Chief + 201 666 8119 FAX jaegerr@bellatlantic.net + 800 HOT OXIDE Douglas W. Cooper, Ph.D., Editor, Aerosol Science dwcooper_99@yahoo.com Susan G. Shami, ScD, Editor, Respiratory Biology and Inhalation Toxicology sshami@bellatlantic.net Arlene L. Weiss, MS, DABT Editor, Air Pollution, Toxicology and Epidemiology iamalw@bellatlantic.net. |